منابع مشابه
Fluorescent labeling of human platelets.
Noncovalently bound fluorescent probes have been used to study changes in the platelet which may occur during platelet aggregation. Platelets were exposed to either N-phenyl-naphthylamine (NPN) or 8-anilino-1-naphthalene-sulfonic acid (ANS). Both dyes were bound by the platelet, and platelet aggregation by collagen or thrombin was unaffected by the presence of the label. No change in fluorescen...
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The ρ1 GABAC receptor is a ligand-gated chloride ion channel that shows promise as a therapeutic target for myopia, sleep disorders, memory and learning facilitation, and anxiety-related disorders. As such, there is a need for molecular probes to understand the role GABAC receptors play in physiological and pathological processes. To date, no labeled (either radioactive or fluorescent) GABAC se...
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Dihydrofolate reductase (DHFR; tetrahydrofolate; NADP' oxidoreductase, EC 1.5.1.3) catalyses the NADPH-dependent reduction of 7,8-dihydrofolate (FAH,) to 5,6,7,8-tetrahydrofolate (FAH,). The coenzyme FAH, serves as a carrier of one-carbon fragments in a number of biosynthetic transfer reactions (Rader & Huennekens, 1973). It is apparent that DHFR is the intracellular target for the anti-cancer ...
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ژورنال
عنوان ژورنال: ACS Medicinal Chemistry Letters
سال: 2012
ISSN: 1948-5875,1948-5875
DOI: 10.1021/ml300191g